The formulation is suitable for
- Tired and devitalized skin
- Moisture lack and dehydration
- Skin with reduced elasticity
- Skin prone to visible redness
- Early signs of aging
- Uneven skin tone and pores
MESO PDRN-tFNA DERMA BOOST & RESTORE
VEGAN · Advanced cosmetic cocktail
Advanced cosmetic cocktail with PDRN and tFNA, containing ingredients known for their skin-care, soothing, and moisturizing properties.
Coming March 1, 2026
See the buttons at the top for detailed information on: Ingredients, Treatment Areas and Results, Instructions for Use, Downloads
Application Areas
- Face
- Neck
- Décolletage
- Hands
- Eye Area
- Scars & unevenness*
- After cosmetic procedures*
*Only on intact skin when the skin barrier is restored.
Active Ingredients
- PDRN – known for skin-care and comfort-giving properties
- Hyaluronic Acid – contributes to moisture
- Peptides – known for supporting the skin's appearance
- Vitamins & Amino Acids – contribute to glow
- Minerals & Essential Lipids – support the skin barrier
- Panthenol & Glycerin – moisture and comfort
MESO PDRN-tFNA DERMA BOOST & RESTORE is an advanced cosmetic formulation that combines PDRN (Polydeoxyribonucleotide) and tFNA (tetrahedral DNA nanostructures). These ingredients are well known from ingredient and supplier studies and are used in cosmetic formulations focusing on skin care, comfort, and a well-groomed appearance.
What are PDRN and tFNA?
- PDRN: A DNA-based active, vegan-produced, known for skin-care properties and used in cosmetic formulations focusing on comfort and care.
- tFNA: Ultrashort DNA-based nanostructures, used for stability and controlled delivery of active ingredients in cosmetic products.
How is the formulation experienced?
The formulation contributes to the skin's appearance of moisture, evenness, and comfort, which can give the skin a more well-groomed and fresh expression.
What can be expected?
- Appearance of improved skin texture
- Skin that appears more moisturized and glowing
- Increased skin comfort
- Suitable for sensitive skin through soothing ingredients
Application in the clinic
- Target group: Professional cosmetic use for skin in need of moisture, care, and comfort.
- Application: Should only be applied to intact skin and not on irritated, damaged, or compromised skin.
The formulation is developed for professional therapists who wish to offer advanced, ingredient-based solutions in cosmetic skin care.
Active Ingredients
A breakthrough in advanced cosmetic formulation
1. PDRN (Polydeoxyribonucleotide)
DNA fragments (vegan)
- Known for skin-care properties
- Contributes to skin comfort and a well-groomed appearance
2. tFNA (Tetrahedral DNA Nanostructures)
Nano-structured DNA fragments
- Used for stability and effective ingredient delivery
- Supports the overall performance of the formulation
3. Hyaluronic Acid
- Contributes to hydration
- Provides volume and moisture
4. Peptides
- Copper peptides – known for skin-care properties
- Tri- and hexapeptides – used in cosmetic care
5. Amino Acids
- Natural components in skin care
- Contribute to the skin’s appearance
6. Vitamins
- Contribute to glow
- Antioxidant protection
7. Antioxidants & Soothing Extracts
- Glutathione
- Centella Asiatica
- Panthenol (Provitamin B5)
Applied Technology
1. PDRN-based Formulation Technology
- Controlled fragment length
- Developed for cosmetic skin care
2. tFNA Nano-Delivery System
- Tetrahedral 3D structure
- Stable and controlled ingredient delivery
3. Mesotherapy-optimized molecular weight
- Developed for professional cosmetic use
- Designed for use with microneedling techniques
4. Antioxidant & Skin Comfort Complex
- Contributes to protection against external influences
- Can help reduce visible redness
5. Barrier-supporting Complex
- Ceramides
- Fatty acids
- NMF components
Unique and Effective Ingredients
- AQUA: Water, used as a solvent.
- GLYCERIN: Moisturizer, helps retain skin moisture.
- PANTHENOL: Moisturizes and provides skin comfort.
- PHENOXYETHANOL: Preservative.
- CALCIUM GLUCONATE: Contributes to the skin's well-groomed appearance.
- MAGNESIUM GLUCONATE: Contributes to skin comfort.
- POTASSIUM GLUCONATE: Helps with moisture balance.
- XANTHAN GUM: Thickening agent.
- SODIUM LACTATE: Moisturizer.
- SODIUM PCA: Natural moisture binder.
- ARGININE: Amino acid used in skin care.
- SODIUM HYALURONATE: Hyaluronic acid, moisture.
- RETINYL PALMITATE: Vitamin A derivative used in cosmetics.
- SODIUM ASCORBYL PHOSPHATE: Stable form of vitamin C.
- POTASSIUM SORBATE: Preservative.
Conclusion
MESO PDRN-tFNA DERMA BOOST & RESTORE is an advanced, vegan cosmetic cocktail developed specifically for professional therapists. The product combines the latest advancements in mesotherapy and cell renewal, making it ideal for treating skin that requires intensive regeneration and care.
The formulation focuses on three essential areas for optimal skin care:
-
Moisture: The specially developed cocktail is rich in ingredients that provide the skin with intense moisture and nourishment, helping to maintain the skin's natural balance and prevent dehydration. This results in smooth, elastic skin that feels healthy and well-groomed.
-
Skin Comfort: The soothing effect of the cocktail provides noticeable relief for the skin, making it ideal after intensive cosmetic treatments such as chemical peels or microneedling. It improves the skin’s texture and reduces redness or irritation, resulting in calm and balanced skin.
-
Well-Groomed Appearance: MESO PDRN-tFNA DERMA BOOST & RESTORE works with the body's natural regeneration processes to create a more even, youthful complexion. The product stimulates collagen production and improves skin firmness and elasticity, providing a fresher, more youthful appearance.
The product can be used as a supplement to professional cosmetic procedures when the skin is intact and the skin barrier is restored. It is ideal for treatment after procedures like microneedling, laser treatments, or chemical peels, where the skin needs extra care and protection.
MESO PDRN-tFNA DERMA BOOST & RESTORE meets the highest professional standards and offers a responsible approach to ingredient-based skin care. The product is 100% vegan and free from unnecessary additives, making it a safe and effective choice for professional therapists who want to offer their clients results that are both documented and based on advanced science.
MESO PDRN-tFNA DERMA BOOST & RESTORE is therefore not just a cosmetic treatment, but an innovative solution that supports the skin's natural processes and creates visible, long-lasting results.
| Ingredients | 498 |
| Treatment Areas and Results | v |
| How to use | 500 |
Ingredients Overview
MESO PIGMENT SOLUTION
Below is a detailed description of the ingredients – structured into clear sections with a focus on efficacy, skin tolerance, and professional use.
Primary active ingredients – targeted pigment reduction
PigmentNiacinamide (Vitamin B3)
- Inhibits the transfer of melanin from melanocytes to keratinocytes
- Reduces the appearance of dark spots and uneven skin tone
- Strengthens the skin barrier and reduces inflammation, which often worsens pigmentation
Alpha-Arbutin
- An effective and stable melanin inhibitor
- Inhibits the enzyme tyrosinase, which is central to melanin production
- Known to brighten existing dark spots without irritating the skin
Tranexamic Acid
- Documented efficacy against melasma and hormonally driven hyperpigmentation
- Reduces UV- and inflammation-induced melanin synthesis
- Highly suitable for sensitive skin with pigmentation concerns
Ascorbyl Glucoside (Stable Vitamin C)
- An antioxidant that inhibits melanin production
- Brightens skin tone and improves clarity and overall evenness
- Protects against free radicals that can trigger new pigmentation
Kojic Acid
- A potent tyrosinase inhibitor
- Reduces dark spots, sun damage, and uneven pigmentation
- Works particularly well in combination with Vitamin C and arbutin
Retinal (Vitamin A Aldehyde)
- Promotes cell renewal and accelerates shedding of pigment-loaded skin cells
- Improves skin texture and reduces accumulated pigmentation over time
- Supports long-term results in the treatment of chronic hyperpigmentation
Soothing, repairing, and barrier-strengthening ingredients
ToleranceAloe Barbadensis Leaf Extract
- Soothes irritated skin and reduces inflammation
- Helps counteract post-inflammatory hyperpigmentation
Panthenol (Provitamin B5)
- Strengthens the skin barrier and supports healing
- Reduces the risk of irritation during pigment-focused treatment
Centella Asiatica Extract
- Anti-inflammatory and reparative
- Reduces redness and pigment-triggering stress in the skin
Pueraria Lobata Root Extract
- Rich in isoflavones with antioxidant activity
- Counteracts oxidative stress, which can stimulate melanocyte activity
Hydrating and delivery-enhancing ingredients
DeliveryGlycerin, Propylene Glycol, Pentylene Glycol, Mannitol
- Intensive moisture binding improves skin tolerance to active ingredients
- Enhances penetration and the effectiveness of pigment-regulating agents
Phosphatidylcholine
- Improves delivery of active ingredients into the skin
- Supports cell membrane function and repair
Antioxidants and protection
ProtectionTocopheryl Acetate (Vitamin E)
- Protects the skin from free radicals
- Helps prevent UV-related worsening of dark spots
Hydrolyzed Brassica Napus Seedcake Extract
- Antioxidant and skin-protective effect
- Supports the skin’s natural defense against environmental stressors
Stability, texture, and preservation
Formulation- Aqua
- Xanthan Gum
- Polyglyceryl-10 Laurate
- Cetyl Alcohol
- Phenoxyethanol
- Ethylhexylglycerin
- Sodium Benzoate
- Potassium Sorbate
- Triethanolamine
Overall professional assessment
ConclusionThis formulation works multidimensionally to address pigmentation concerns by:
- Inhibiting melanin production (arbutin, kojic acid, tranexamic acid)
- Reducing inflammation and post-inflammatory pigmentation
- Promoting cell renewal and replacement of pigment-loaded skin cells (retinal)
- Protecting against new pigmentation changes via antioxidants
- Ensuring high skin tolerance and optimal penetration
Suitable for treating:
- Sun damage and age spots
- Melasma
- Post-inflammatory hyperpigmentation
- Uneven skin tone and pigment-related skin stress
Ingredients
-
Aqua (Water)
• Description: Purified, de-ionised water base
• Origin: Distilled/filtered water
• Function: Universal solvent / carrier, provides basic hydration -
Glycerin
• Description: Trivalent sugar alcohol (classic humectant)
• Origin: Vegetable oils (rapeseed/soy) or biodiesel by-product
• Function: Binds water in the stratum corneum → “plumps” dehydration lines -
Phospholipids
• Description: Skin-identical phospholipids (lecithin fraction)
• Origin: Extracted from soy or sunflower lecithin
• Function: Repairs lipid barrier, forms lamellar structures, increases penetration of actives -
Citrullus Lanatus (Watermelon) Fruit Extract
• Description: Fruit extract rich in lycopene, minerals and amino acids
• Origin: Watermelon flesh/rind (food by-product)
• Function: Antioxidant protection against UV-ROS, light hydration and soothing -
Citrus Paradisi (Grapefruit) Fruit Extract
• Description: Extract containing AHAs and vitamin C
• Origin: Cold-pressed peel and pulp of grapefruit
• Function: Mild chemical exfoliation, antibacterial, fresher complexion -
Momordica Charantia Fruit Extract
• Description: Bitter-melon extract with charantin & momordicin
• Origin: Fruit of Momordica charantia
• Function: Anti-inflammatory, prebiotic; calms redness & strengthens microbiome -
Phenoxyethanol
• Description: Aromatic alcohol preservative
• Origin: Synthetic (petro-/phenol origin)
• Function: Broad-spectrum antimicrobial – ensures product shelf life -
Xanthan Gum
• Description: Natural polysaccharide gel
• Origin: Fermentation of corn or sugar-molasses (Xanthomonas bacteria)
• Function: Thickening; stabilises viscosity and prevents phase separation -
Sodium Lactate
• Description: Sodium salt of lactic acid; part of the skin’s NMF
• Origin: Fermentation of sugar beet/corn
• Function: Humectant, slight pH-buffering effect -
PCA (Pyrrolidone Carboxylic Acid)
• Description: Organic acid – natural moisturising factor
• Origin: Biosynthesis from glutamic acid
• Function: Binds moisture; keeps skin supple and elastic -
Sodium PCA
• Description: Sodium salt of PCA (more water-soluble)
• Origin: As above, neutralised with NaOH
• Function: Extra-high moisture binding; counteracts tightness -
Arginine
• Description: Basic α-amino acid
• Origin: Fermentation of sugarcane/corn
• Function: pH-buffer, moisturiser, supports wound-healing & micro-circulation -
Ethylhexylglycerin
• Description: Multifunctional emollient / preservative booster
• Origin: Vegetable glycerol + ethylhexyl group (semi-synthetic)
• Function: Enhances phenoxyethanol, softens skin surface -
Aspartic Acid
• Description: Acidic amino acid in NMF
• Origin: Microbial fermentation
• Function: Maintains moisture balance; substrate for protein synthesis (collagen) -
Disodium EDTA
• Description: Chelating agent (salt of ethylenediaminetetraacetic acid)
• Origin: Synthetic
• Function: Binds metal ions → stabilises formula & preservation system -
Sorbitol
• Description: Hexavalent sugar alcohol
• Origin: Hydrolysis / hydrogenation of corn- or potato-starch
• Function: Humectant; reduces drying-out and crystallisation -
Lecithin
• Description: Mixed phospholipids (PC, PE etc.)
• Origin: Soybeans or sunflower seeds
• Function: Natural emulsifier; repairs barrier; improves penetration -
Citric Acid
• Description: Alpha-hydroxy acid (AHA)
• Origin: Citrus fruits or fermentation of sugar-molasses
• Function: Adjusts pH; very mild exfoliation; refines skin surface -
Tocopheryl Acetate (Vitamin E)
• Description: Stable ester of tocopherol
• Origin: Esterified vitamin E from plant oils
• Function: Fat-soluble antioxidant – protects membrane lipids & collagen -
Amino-acid blend (Phenylalanine, Valine, Serine, Threonine, Glycine, Histidine, Alanine, Proline, Isoleucine)
• Origin: Fermentation of glucose/corn (biotechnological)
• Function: Building blocks for collagen & elastin; increase moisture and elasticity -
Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake)
• Description: Synthetic tripeptide that mimics snake venom
• Origin: Chemical synthesis (peptide laboratory)
• Function: Temporary neuromuscular inhibition ⇒ botox-like smoothing of expression lines -
Glyceryl Linoleate
• Description: Ester of glycerin + linoleic acid (omega-6)
• Origin: Safflower- or sunflower-oil (pre-saponification / esterification)
• Function: Repairs lipid barrier; calms inflammation; increases suppleness -
Glyceryl Linolenate
• Description: Ester of glycerin + α-linolenic acid (omega-3)
• Origin: Flaxseed- or rapeseed-oil
• Function: Anti-inflammatory; soothes irritation; strengthens barrier -
Sodium Ascorbyl Phosphate
• Description: Water-soluble, stable vitamin C derivative
• Origin: Synthetic (ascorbic acid + phosphate + sodium)
• Function: Antioxidant; stimulates collagen; brightens dark spots -
Retinyl Palmitate
• Description: Ester of retinol + palmitic acid (vitamin A derivative)
• Origin: Synthetic / plant-derived
• Function: Increases cell turnover; smooths skin; regulates sebum; boosts collagen -
Potassium Sorbate
• Description: Salt of sorbic acid (mild preservative)
• Origin: Synthetic (originally sorbic acid from rowan berries)
• Function: Inhibits yeast and mould – keeps product safe
Synergy for anti-age
The combination of Syn-Ake (rapid smoothing) + vitamins A/C/E (long-term rebuilding & antioxidant) + amino acids & lipids (barrier/collagen support) + plant-extract antioxidants provides both immediate and lasting improvements in lines, firmness and skin tone, while helping prevent future signs of ageing.
The technique behind the production of MESO EXOCELL VOLUME
Phase |
What happens |
Why it’s important |
|---|---|---|
| 1. Cell source & cultivation |
|
Creates “bio-authentic” exosomes with the same lipid signature and signalling proteins as the skin’s own. |
| 2. Harvest & isolation of exosomes |
|
Provides high purity (>95 %) and intact membrane structure → optimal cell communication. |
| 3. Characterisation & QC |
|
Documents that exosomes are safe, sterile and biologically active. |
| 4. Lyophilisation & stabilisation |
|
Makes the product shelf-stable at 2–8 °C and resistant to transport stress. |
| 5. Peptide synthesis (Syn-Ake) |
|
Ensures consistent neuromuscular inhibition (botox-like) without immunogenicity. |
| 6. Formulation (nano-emulsion) |
|
Forms a stable nano-emulsion; phospholipids help exosomes and peptides pass through the stratum corneum. |
Key points in the technology
- Bio-authentic exosome delivery system™ – mimics natural cell communication, boosts fibroblast glycolysis and collagen production.
- Peptide/exosome synergy – Syn-Ake reduces micro-contractions while exosomes stimulate tissue building → double anti-age effect.
- Lyophilisation + phospholipid nano-emulsion – combines long shelf life with high cutaneous penetration without needles.