Ingredients

• Aqua (Water)
  • Description: Purified, de-ionised water base
  • Origin: Distilled/filtered water
  • Function: Universal solvent / carrier, provides basic hydration

• Glycerin
  • Description: Trivalent sugar alcohol (classic humectant)
  • Origin: Vegetable oils (rapeseed/soy) or biodiesel by-product
  • Function: Binds water in the stratum corneum → “plumps” dehydration lines

• Phospholipids
  • Description: Skin-identical phospholipids (lecithin fraction)
  • Origin: Extracted from soy or sunflower lecithin
  • Function: Repairs lipid barrier, forms lamellar structures, increases penetration of actives

• Citrullus Lanatus (Watermelon) Fruit Extract
  • Description: Fruit extract rich in lycopene, minerals and amino acids
  • Origin: Watermelon flesh/rind (food by-product)
  • Function: Antioxidant protection against UV-ROS, light hydration and soothing

• Citrus Paradisi (Grapefruit) Fruit Extract
  • Description: Extract containing AHAs and vitamin C
  • Origin: Cold-pressed peel and pulp of grapefruit
  • Function: Mild chemical exfoliation, antibacterial, fresher complexion

• Momordica Charantia Fruit Extract
  • Description: Bitter-melon extract with charantin & momordicin
  • Origin: Fruit of Momordica charantia
  • Function: Anti-inflammatory, prebiotic; calms redness & strengthens microbiome

• Phenoxyethanol
  • Description: Aromatic alcohol preservative
  • Origin: Synthetic (petro-/phenol origin)
  • Function: Broad-spectrum antimicrobial – ensures product shelf life

• Xanthan Gum
  • Description: Natural polysaccharide gel
  • Origin: Fermentation of corn or sugar-molasses (Xanthomonas bacteria)
  • Function: Thickening; stabilises viscosity and prevents phase separation

• Sodium Lactate
  • Description: Sodium salt of lactic acid; part of the skin’s NMF
  • Origin: Fermentation of sugar beet/corn
  • Function: Humectant, slight pH-buffering effect

• PCA (Pyrrolidone Carboxylic Acid)
  • Description: Organic acid – natural moisturising factor
  • Origin: Biosynthesis from glutamic acid
  • Function: Binds moisture; keeps skin supple and elastic

• Sodium PCA
  • Description: Sodium salt of PCA (more water-soluble)
  • Origin: As above, neutralised with NaOH
  • Function: Extra-high moisture binding; counteracts tightness

• Arginine
  • Description: Basic α-amino acid
  • Origin: Fermentation of sugarcane/corn
  • Function: pH-buffer, moisturiser, supports wound-healing & micro-circulation

• Ethylhexylglycerin
  • Description: Multifunctional emollient / preservative booster
  • Origin: Vegetable glycerol + ethylhexyl group (semi-synthetic)
  • Function: Enhances phenoxyethanol, softens skin surface

• Aspartic Acid
  • Description: Acidic amino acid in NMF
  • Origin: Microbial fermentation
  • Function: Maintains moisture balance; substrate for protein synthesis (collagen)

• Disodium EDTA
  • Description: Chelating agent (salt of ethylenediaminetetraacetic acid)
  • Origin: Synthetic
  • Function: Binds metal ions → stabilises formula & preservation system

• Sorbitol
  • Description: Hexavalent sugar alcohol
  • Origin: Hydrolysis / hydrogenation of corn- or potato-starch
  • Function: Humectant; reduces drying-out and crystallisation

• Lecithin
  • Description: Mixed phospholipids (PC, PE etc.)
  • Origin: Soybeans or sunflower seeds
  • Function: Natural emulsifier; repairs barrier; improves penetration

• Citric Acid
  • Description: Alpha-hydroxy acid (AHA)
  • Origin: Citrus fruits or fermentation of sugar-molasses
  • Function: Adjusts pH; very mild exfoliation; refines skin surface

• Tocopheryl Acetate (Vitamin E)
  • Description: Stable ester of tocopherol
  • Origin: Esterified vitamin E from plant oils
  • Function: Fat-soluble antioxidant – protects membrane lipids & collagen

• Amino-acid blend (Phenylalanine, Valine, Serine, Threonine, Glycine, Histidine, Alanine, Proline, Isoleucine)
  • Origin: Fermentation of glucose/corn (biotechnological)
  • Function: Building blocks for collagen & elastin; increase moisture and elasticity

• Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake)
  • Description: Synthetic tripeptide that mimics snake venom
  • Origin: Chemical synthesis (peptide laboratory)
  • Function: Temporary neuromuscular inhibition ⇒ botox-like smoothing of expression lines

• Glyceryl Linoleate
  • Description: Ester of glycerin + linoleic acid (omega-6)
  • Origin: Safflower- or sunflower-oil (pre-saponification / esterification)
  • Function: Repairs lipid barrier; calms inflammation; increases suppleness

• Glyceryl Linolenate
  • Description: Ester of glycerin + α-linolenic acid (omega-3)
  • Origin: Flaxseed- or rapeseed-oil
  • Function: Anti-inflammatory; soothes irritation; strengthens barrier

• Sodium Ascorbyl Phosphate
  • Description: Water-soluble, stable vitamin C derivative
  • Origin: Synthetic (ascorbic acid + phosphate + sodium)
  • Function: Antioxidant; stimulates collagen; brightens dark spots

• Retinyl Palmitate
  • Description: Ester of retinol + palmitic acid (vitamin A derivative)
  • Origin: Synthetic / plant-derived
  • Function: Increases cell turnover; smooths skin; regulates sebum; boosts collagen

• Potassium Sorbate
  • Description: Salt of sorbic acid (mild preservative)
  • Origin: Synthetic (originally sorbic acid from rowan berries)
  • Function: Inhibits yeast and mould – keeps product safe

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Synergy for anti-age
The combination of Syn-Ake (rapid smoothing) + vitamins A/C/E (long-term rebuilding & antioxidant) + amino acids & lipids (barrier/collagen support) + plant-extract antioxidants provides both immediate and lasting improvements in lines, firmness and skin tone, while helping prevent future signs of ageing.

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The technique behind the production of MESO EXOCELL VOLUME

Phase	What happens	Why it’s important
1. Cell source & cultivation	Human, skin-compatible progenitor cells (non-embryonic) are used. Cultured in a closed, serum-free medium under GMP conditions to avoid animal contaminants.	Creates “bio-authentic” exosomes with the same lipid signature and signalling proteins as the skin’s own.
2. Harvest & isolation of exosomes	The culture undergoes mild ultracentrifugation, tangential-flow filtration (TFF) and micro-fluidic size-exclusion. Vesicles 30-150 nm are collected while larger debris is removed.	Provides high purity (>95 %) and intact membrane structure → optimal cell communication.
3. Characterisation & QC	Nanoparticle Tracking Analysis (NTA) measures particle size and concentration. Western blot / ELISA confirms exosome markers (CD63, CD81, TSG101). Endotoxin, mycoplasma and sterility tests are performed.	Documents that exosomes are safe, sterile and biologically active.
4. Lyophilisation & stabilisation	Exosomes are mixed with cryoprotectants (trehalose, sucrose) and freeze-dried at −40 °C / <10⁻³ mbar. The result is a stable, hygroscopic powder retaining >90 % bioactivity after rehydration.	Makes the product shelf-stable at 2–8 °C and resistant to transport stress.
5. Peptide synthesis (Syn-Ake)	The tripeptide is synthesised via solid-phase peptide synthesis (SPPS) with Fmoc chemistry. Purified by RP-HPLC to >98 % purity and tested for heavy metals / solvent residues.	Ensures consistent neuromuscular inhibition (botox-like) without immunogenicity.
6. Formulation (nano-emulsion)	Lyophilisate of exosomes, Syn-Ake, vitamin E acetate, glycerin and phospholipids are dissolved in buffer and emulsified by low-shear ultrasonics. pH adjusted to 6.2–6.5 (skin-neutral).	Forms a stable nano-emulsion; phospholipids help exosomes and peptides pass through the stratum corneum.

Key points in the technology

1. Bio-authentic exosome delivery system™ – mimics natural cell communication, boosts fibroblast glycolysis and collagen production.
2. Peptide/exosome synergy – Syn-Ake reduces micro-contractions while exosomes stimulate tissue building → double anti-age effect.
3. Lyophilisation + phospholipid nano-emulsion – combines long shelf life with high cutaneous penetration without needles.