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Ingredients

  • Aqua (Water)
    • Description: Purified, de-ionised water base
    • Origin: Distilled/filtered water
    • Function: Universal solvent / carrier, provides basic hydration

  • Glycerin
    • Description: Trivalent sugar alcohol (classic humectant)
    • Origin: Vegetable oils (rapeseed/soy) or biodiesel by-product
    • Function: Binds water in the stratum corneum → “plumps” dehydration lines

  • Phospholipids
    • Description: Skin-identical phospholipids (lecithin fraction)
    • Origin: Extracted from soy or sunflower lecithin
    • Function: Repairs lipid barrier, forms lamellar structures, increases penetration of actives

  • Citrullus Lanatus (Watermelon) Fruit Extract
    • Description: Fruit extract rich in lycopene, minerals and amino acids
    • Origin: Watermelon flesh/rind (food by-product)
    • Function: Antioxidant protection against UV-ROS, light hydration and soothing

  • Citrus Paradisi (Grapefruit) Fruit Extract
    • Description: Extract containing AHAs and vitamin C
    • Origin: Cold-pressed peel and pulp of grapefruit
    • Function: Mild chemical exfoliation, antibacterial, fresher complexion

  • Momordica Charantia Fruit Extract
    • Description: Bitter-melon extract with charantin & momordicin
    • Origin: Fruit of Momordica charantia
    • Function: Anti-inflammatory, prebiotic; calms redness & strengthens microbiome

  • Phenoxyethanol
    • Description: Aromatic alcohol preservative
    • Origin: Synthetic (petro-/phenol origin)
    • Function: Broad-spectrum antimicrobial – ensures product shelf life

  • Xanthan Gum
    • Description: Natural polysaccharide gel
    • Origin: Fermentation of corn or sugar-molasses (Xanthomonas bacteria)
    • Function: Thickening; stabilises viscosity and prevents phase separation

  • Sodium Lactate
    • Description: Sodium salt of lactic acid; part of the skin’s NMF
    • Origin: Fermentation of sugar beet/corn
    • Function: Humectant, slight pH-buffering effect

  • PCA (Pyrrolidone Carboxylic Acid)
    • Description: Organic acid – natural moisturising factor
    • Origin: Biosynthesis from glutamic acid
    • Function: Binds moisture; keeps skin supple and elastic

  • Sodium PCA
    • Description: Sodium salt of PCA (more water-soluble)
    • Origin: As above, neutralised with NaOH
    • Function: Extra-high moisture binding; counteracts tightness

  • Arginine
    • Description: Basic α-amino acid
    • Origin: Fermentation of sugarcane/corn
    • Function: pH-buffer, moisturiser, supports wound-healing & micro-circulation

  • Ethylhexylglycerin
    • Description: Multifunctional emollient / preservative booster
    • Origin: Vegetable glycerol + ethylhexyl group (semi-synthetic)
    • Function: Enhances phenoxyethanol, softens skin surface

  • Aspartic Acid
    • Description: Acidic amino acid in NMF
    • Origin: Microbial fermentation
    • Function: Maintains moisture balance; substrate for protein synthesis (collagen)

  • Disodium EDTA
    • Description: Chelating agent (salt of ethylenediaminetetraacetic acid)
    • Origin: Synthetic
    • Function: Binds metal ions → stabilises formula & preservation system

  • Sorbitol
    • Description: Hexavalent sugar alcohol
    • Origin: Hydrolysis / hydrogenation of corn- or potato-starch
    • Function: Humectant; reduces drying-out and crystallisation

  • Lecithin
    • Description: Mixed phospholipids (PC, PE etc.)
    • Origin: Soybeans or sunflower seeds
    • Function: Natural emulsifier; repairs barrier; improves penetration

  • Citric Acid
    • Description: Alpha-hydroxy acid (AHA)
    • Origin: Citrus fruits or fermentation of sugar-molasses
    • Function: Adjusts pH; very mild exfoliation; refines skin surface

  • Tocopheryl Acetate (Vitamin E)
    • Description: Stable ester of tocopherol
    • Origin: Esterified vitamin E from plant oils
    • Function: Fat-soluble antioxidant – protects membrane lipids & collagen

  • Amino-acid blend (Phenylalanine, Valine, Serine, Threonine, Glycine, Histidine, Alanine, Proline, Isoleucine)
    • Origin: Fermentation of glucose/corn (biotechnological)
    • Function: Building blocks for collagen & elastin; increase moisture and elasticity

  • Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake)
    • Description: Synthetic tripeptide that mimics snake venom
    • Origin: Chemical synthesis (peptide laboratory)
    • Function: Temporary neuromuscular inhibition ⇒ botox-like smoothing of expression lines

  • Glyceryl Linoleate
    • Description: Ester of glycerin + linoleic acid (omega-6)
    • Origin: Safflower- or sunflower-oil (pre-saponification / esterification)
    • Function: Repairs lipid barrier; calms inflammation; increases suppleness

  • Glyceryl Linolenate
    • Description: Ester of glycerin + α-linolenic acid (omega-3)
    • Origin: Flaxseed- or rapeseed-oil
    • Function: Anti-inflammatory; soothes irritation; strengthens barrier

  • Sodium Ascorbyl Phosphate
    • Description: Water-soluble, stable vitamin C derivative
    • Origin: Synthetic (ascorbic acid + phosphate + sodium)
    • Function: Antioxidant; stimulates collagen; brightens dark spots

  • Retinyl Palmitate
    • Description: Ester of retinol + palmitic acid (vitamin A derivative)
    • Origin: Synthetic / plant-derived
    • Function: Increases cell turnover; smooths skin; regulates sebum; boosts collagen

  • Potassium Sorbate
    • Description: Salt of sorbic acid (mild preservative)
    • Origin: Synthetic (originally sorbic acid from rowan berries)
    • Function: Inhibits yeast and mould – keeps product safe

Synergy for anti-age
The combination of Syn-Ake (rapid smoothing) + vitamins A/C/E (long-term rebuilding & antioxidant) + amino acids & lipids (barrier/collagen support) + plant-extract antioxidants provides both immediate and lasting improvements in lines, firmness and skin tone, while helping prevent future signs of ageing.

The technique behind the production of MESO EXOCELL VOLUME

Phase

What happens

Why it’s important
1. Cell source & cultivation
  • Human, skin-compatible progenitor cells (non-embryonic) are used.
  • Cultured in a closed, serum-free medium under GMP conditions to avoid animal contaminants.
 Creates “bio-authentic” exosomes with the same lipid signature and signalling proteins as the skin’s own.
2. Harvest & isolation of exosomes
  • The culture undergoes mild ultracentrifugation, tangential-flow filtration (TFF) and micro-fluidic size-exclusion.
  • Vesicles 30-150 nm are collected while larger debris is removed.
 Provides high purity (>95 %) and intact membrane structure → optimal cell communication.
3. Characterisation & QC
  • Nanoparticle Tracking Analysis (NTA) measures particle size and concentration.
  • Western blot / ELISA confirms exosome markers (CD63, CD81, TSG101).
  • Endotoxin, mycoplasma and sterility tests are performed.
 Documents that exosomes are safe, sterile and biologically active.
4. Lyophilisation & stabilisation
  • Exosomes are mixed with cryoprotectants (trehalose, sucrose) and freeze-dried at −40 °C / <10⁻³ mbar.
  • The result is a stable, hygroscopic powder retaining >90 % bioactivity after rehydration.
 Makes the product shelf-stable at 2–8 °C and resistant to transport stress.
5. Peptide synthesis (Syn-Ake)
  • The tripeptide is synthesised via solid-phase peptide synthesis (SPPS) with Fmoc chemistry.
  • Purified by RP-HPLC to >98 % purity and tested for heavy metals / solvent residues.
 Ensures consistent neuromuscular inhibition (botox-like) without immunogenicity.
6. Formulation (nano-emulsion)
  • Lyophilisate of exosomes, Syn-Ake, vitamin E acetate, glycerin and phospholipids are dissolved in buffer and emulsified by low-shear ultrasonics.
  • pH adjusted to 6.2–6.5 (skin-neutral).
 Forms a stable nano-emulsion; phospholipids help exosomes and peptides pass through the stratum corneum.

Key points in the technology

  1. Bio-authentic exosome delivery system™ – mimics natural cell communication, boosts fibroblast glycolysis and collagen production.
  2. Peptide/exosome synergy – Syn-Ake reduces micro-contractions while exosomes stimulate tissue building → double anti-age effect.
  3. Lyophilisation + phospholipid nano-emulsion – combines long shelf life with high cutaneous penetration without needles.
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